Arrhythmogenic effects of isoflurane‐induced preconditioning in the isolated rat heart

ischaemic preconditioning in isolated rat heart

Objective: To assess whether the protective effect of ischaemic preconditioning (IPC) on endothelial function in coronary arteries of the rat involves prostaglandins. Methods: Isolated rat hearts perfused under constant flow conditions were exposed to 30 min of partial ischaemia (flow-rate 1 ml /min) followed by 20 min of reperfusion, after which coronaries were precontracted with U-46619 0.1 m...

Preconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model

Abstract Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effect...

Phenylephrine produces late pharmacological preconditioning in the isolated rat heart.

We assume that phenylephrine produces late pharmacological preconditioning through the opening of the mitochondrial KATP channels. To test this hypothesis, rat hearts were isolated and perfused with Krebs buffer solution by Langendorff method and subjected to 30 min regional ischemia followed by 60 min of reperfusion. In this study, phenylephrine as a selective alpha1-adrenoceptor agonist and 5...

Effects of ketamine and its isomers on ischemic preconditioning in the isolated rat heart.

BACKGROUND Ischemic preconditioning protects the heart against subsequent ischemia. Opening of the adenosine triphosphate-sensitive potassium (KATP) channel is a key mechanism of preconditioning. Ketamine blocks KATP channels of isolated cardiomyocytes. The authors investigated the effects of ketamine and its stereoisomers on preconditioning. METHODS Isolated rat hearts (n = 80) underwent 30 ...

effects of pharmacologic preconditioning with natural honey on the left ventricle perfusion pressure in isolated heart